PLOS strives to publish scientific research with transparency, openness, and integrity. Whether that means giving authors the choice to preregister their study, publish peer review comments, or diversifying publishing outputs; we’re here to
Category Archives: Aggregators
Filling in the Scientific Record: The Importance of Negative and Null Results
PLOS strives to publish scientific research with transparency, openness, and integrity. Whether that means giving authors the choice to preregister their study, publish peer review comments, or diversifying publishing outputs; we’re here to support researchers as they work to uncover and communicate discoveries that advance scientific progress. Negative and null results are an important part of this process.
This is something we agree on across our journal portfolio — the most recent updates from PLOS Biology being one example– and it’s something we care about especially on PLOS ONE. Our journal’s mission is to provide researchers with a quality, peer-reviewed and Open Access venue for all rigorously conducted research, regardless of novelty or impact. Our role in the publishing ecosystem is to provide a complete, transparent view of scientific literature to enable discovery. While negative and null results can often be overlooked — by authors and publishers alike — their publication is equally as important as positive outcomes and can help fill in critical gaps in the scientific record.
We encourage researchers to share their negative and null results.
To provide checks and balances for emerging research
Positive results are often viewed as more impactful. From authors, editors, and publishers alike, there is a tendency to favor the publication of positive results over negative ones and, yes, there is evidence to suggest that positive results are more frequently cited by other researchers.
Negative results, however, are crucial to providing a system of checks and balances against similar positive findings. Studies have attempted to determine to what extent the lack of negative results in scientific literature has inflated the efficacy of certain treatments or allowed false positives to remain unchecked.
The effect is particularly dramatic in meta-analyses which are typically undertaken with the assumption that the sample of retrieved studies is representative of all conducted studies:
“However, it is clear that a positive bias is introduced when studies with negative results remain unreported, thereby jeopardizing the validity of meta-analysis (25, 26). This is potentially harmful as the false positive outcome of meta-analysis misinforms researchers, doctors, policymakers and greater scientific community, specifically when the wrong conclusions are drawn on the benefit of the treatment.”
— Mlinari?, et al (2017). Dealing with publication bias: why you should really publish your negative results. Biochem Med (Zagreb) 27(3): 030201
As important as it is to report on studies that show a positive effect, it is equally vital to document instances where the same processes were not effective. We should be actively reporting, evaluating, and sharing negative and null results with the same emphasis we give to positive outcomes.
To reduce time and resources needed for researchers to continue investigation
Regardless of the outcomes, new research requires time and financial resources to complete. At the end of the process, something is learned — even if the answer is unexpected or less clear than you had hoped for. Nevertheless, these efforts can provide valuable insights to other research groups.
If you’re seeking the answer to a particular scientific question, chances are that another research group is looking for that answer as well: either as a main focus or to provide additional background for a different study. Independent verification of the results through replication studies are also an important piece of solidifying the foundation of future research. This also can only happen when researchers have a complete record of previous results to work from.
By making more findings available, we can help increase efficiencies and advance scientific discovery faster.
To fill in the scientific record and increase reproducibility
It’s difficult to draw reliable conclusions from a set of data that we know is incomplete. This lack of information affects the entire scientific ecosystem. Readers are often unaware that negative results for a particular study may even exist, and it may even be more difficult for researchers to replicate studies where pieces of the data have been left out of the published record.
Some researchers opt to obtain specific null and negative results from outside the published literature, from non peer-reviewed depositories, or by requesting data directly from the authors. The inclusions of this “grey literature” can improve accuracy, but the additional time and effort that goes into obtaining and verifying this information would be prohibitive for many to include.
This is where publishers can play a pivotal role in ensuring that authors not only feel welcome to submit and publish negative results, but to make sure those efforts are properly recognized and credited. Published, peer-reviewed results allow for a more complete analysis of all available data and increased trust in the scientific record.
We know it’s difficult to get into the lab right now and many researchers are having to rethink the way that they work or focus on other projects. We encourage anyone with previously unpublished negative and null results to submit their work to PLOS ONE and help fill in the gaps of the scientific record, or consider doing so in the future.
The post Filling in the Scientific Record: The Importance of Negative and Null Results appeared first on EveryONE.
EveryONE: Nadine Kabbani
Dr. Kabbani is a Systems Biologist at the School of Systems Biology, George Mason University, Fairfax, Virginia, United States of America What is your area of study and why is it important? I am interested
EveryONE: Yvonne Fondufe-Mittendorf
Note: this is the second of a series of posts in which you’ll get a glimpse into the important work that PLOS ONE authors are performing. Today we’re showcasing Yvonne Fondufe-Mittendorf from the department of
EveryONE: Owen Tomlinson
Note: this is the first of a series of posts in which you’ll get a glimpse into the important work that PLOS ONE authors are performing. Today we’re showcasing Owen Tomlinson from the Children’s Health
“We need to commit to and invest in the changes we seek”: Insights from the MSF Scientific Research Day
In recognition of World Humanitarian Day 2018, PLOS ONE Senior Editor Adya Misra reflects on the Medecines Sans Frontières Scientific Research Day held earlier this year. Medecines Sans Frontières (MSF) are perhaps best known for
Call for Papers: Open Biomaterials Research
0000-0002-9890-5451 We are excited to share a call for papers for research across all areas of biomaterials. Together with our Guest Editors, we are providing an innovative home for interdisciplinary work in biomaterials with the
A tour through six continents: 10 years of new species published in PLOS ONE
Accompanying the new PLOS ONE 10 Year Anniversary Collection: New Species, PLOS ONE Associate Editor Anna Simonin discusses the discovery of organisms around the world first described in PLOS ONE. Despite over 1.2 million
The policy impact of scientific research: looking back at 10 years of PLOS ONE
To continue with PLOS ONE’s 10th anniversary celebration, Associate Editor Sara Fuentes Perez highlights some of the articles that have gained attention from policy makers in the PLOS ONE 10 Year Anniversary: Policy Impact Collection.
Announcing the PLOS ONE Tenth Anniversary T-Shirt Design Contest – enter by June 30
Do you have a great image in your PLOS ONE article or an original design that is representative of the journal? Send it to us! Email your design to email@example.com by Friday, June 30,
PLOS ONE 10 Year Anniversary: Staff Editors’ Favorites
In the first of the PLOS ONE 10th Anniversary Collections, the Staff Editors of the journal have each chosen their favorite PLOS ONE article from the 10 year archive. In this accompanying EveryONE blog, the editors have
Introducing the New PLOS Video Shorts
In 2011, PLOS ONE launched a series of short instructional videos to help our authors, reviewers, and Academic Editors navigate Editorial Manager, our online submission system. We recently updated and expanded these video shorts to provide a resource for PLOS authors, … Continue reading
The post Introducing the New PLOS Video Shorts appeared first on EveryONE.
We Want the Funk: The Ups and Downs of Wild Microbes in Beer
Funky, floral, complex. No, this is not a description of a piece of vintage wallpaper. These are some of the words that are used to describe the enormous variety that exists within the world of beer. Whether you are enjoying … Continue reading
The post We Want the Funk: The Ups and Downs of Wild Microbes in Beer appeared first on EveryONE.
PLOS ONE’s Top 5 Videos of 2015 (So Far)
At the end of 2014, we highlighted some of our favorite research videos from that year. We’re only mid-way through 2015, but we already have a number of popular research videos that we’d like to share. Here are some of … Continue reading
The post PLOS ONE’s Top 5 Videos of 2015 (So Far) appeared first on EveryONE.
I Know What You Think: Collective Intelligence in Online Communication
Have you ever wondered what factors may shape the interactions we have in online chatrooms? With the advent of the Internet 20+ years ago, the ways in which we communicate have drastically changed, allowing us to easily interact nonverbally or … Continue reading
The post I Know What You Think: Collective Intelligence in Online Communication appeared first on EveryONE.