Issue 4/2013 of ChemistyOpen is now available via Wiley Online Library and the journal’s homepage: www.chemistryopen.org.

The current issue covers a great range of interesting topics in bioorganic chemistry and materials science. Todd Lowary and co-workers focus on the synthesis of a tolerance-inducing immunomodulatory pentasaccharide lacto-N-fucopentaose III and its corresponding human serum albumin conjugate. Also in the field of bioorganic chemistry, Hans-Achim Wagenknecht, Ralph Witzgall and colleagues designed and synthesized photochemically active chromophore–nucleic acid conjugates to allow imaging in cells using both fluorescence microscopy and electron microscopy. An analytical biochemical application is also the main focus of the article by James Rusling and co-workers. They developed an inkjet-printed gold nanoparticle immunoarray integrated into a microfluidic device for multiple protein determinations. This detection method can be tuned either for ultrasensitive detection or for rapid detection of biomarkers within clinically relevant detection ranges. Michael Mehring and colleagues, on the other hand, synthesize ?-Bi₂O₃ nanoparticles as promising materials for their application in water purification systems. They developed a straightforward synthetic procedure for the synthesis of ?-Bi₂O₃ nanoparticles and show that they have high photocatalytic activity and stability during the degradation of typical organic water pollutants under visible light irradiation.

 If you are interested in reading the original articles, click here to access the current issue! All articles published in ChemistryOpen are open access to everyone.

The current ChemistryOpen issue features the group of F. Matthias Bickelhaupt and their computational work on geometries adopted by d¹⁰-ML₂ transition-metal complexes. The front cover and cover profile nicely complement their Full Paper and give interesting and valuable background information on their work and the incentive behind it. The Full Paper by Marc Steinmetz and Stefan Grimme presents a further computational paper that reports on an extensive benchmark for evaluating modern density functionals in transition-metal-catalyzed bond-activation reactions.

 Two other papers in this issue also revolve around transition metals. Yan-Yan Song, Patrik Schmuki and co-workers use self-organized TiO₂-nanotube layers in combination with CdTe quantum dots for immunoassay-type detection and achieve excellent detection limits with this electrochemiluminescent technique. Narayane S. Hosmane and colleagues, on the other hand, synthesize nanocomposites of Fe₁₀BO₃/Fe₃O₄/SiO₂ and GdFeO₃/Fe₃O₄/SiO₂ using a gel combustion technique for potential applications in diagnostic analysis of cancer through use in neutron capture therapy.

 All articles published in ChemistryOpen are open access and open to all readers. Click here to access the current issue now!

ChemistryOpen’s first issue in 2013  again reflects the great diversity of this open-access general chemistry journal. Thematically the contributions range from betulin-based polyurethanes for CO₂ adsorption to Cu₂O-decorated TiO₂ nanotubes. In addition to Full Papers, Communications and a Thesis Summary, this issue presents an Editorial by the Co-Editors-in-Chief and a newly featured Cover Profile.

In their Editorial entitled Show me the Money – How, as a Chemist, Can I Find Funding for Open-Access Publishing? the Editors of ChemistryOpen may answer some questions towards open-access funding and provide authors with ideas for potential funding sources. Fuelled by new policies from funders, more and more chemists are looking to publish their research results in an open-access forum. Of course, high-quality publishing costs money, and as a consequence, the so called “gold road” or “author-pays” model has emerged where an Article Publication Charge is payable by the author. So, the question now arises on how authors can meet the associated cost.

ChemistyOpen’s cover receives a new look in 2013 and features the Full Paper by Knut Rurack and co-workers (BAM Federal Institute for Materials Research and Testing, Berlin, Germany) on fluorinated BODIPY dyes for dual-method surface analysis. The associated Cover Profile lets readers around the world take a closer look at his group in Berlin and offers a glimpse at the motivation behind their work: “When one tries to assess the functionalization degree of a support quantitatively, that is, the concentration of chemical groups across the entire support, one realizes that there are no reliable methods available today.“

All articles published in ChemistryOpen are open-access and free to all readers. Click here to access the current issue now!

ChemistryOpen’s sixth Issue is now online and free to read, download and share.
This last issue in 2012 covers topics ranging from bibliometrics and oxidative rearrangements to molecular recognition in glycoaldehyde.

R. Martínez-Mánez and co-workers present their work on detecting finasteride, a steroid used in sports for doping. To do so, they use mesoporous silica nanoparticles that are functionalized with a finasteride derivative. They then load the nanoparticles with the fluorescent dye, rhodamine B, and cap them with an anti-finasteride antibody. The dye is trapped inside the mesopores and is only released when surrounding finasteride competes for binding to the antibodies, which then leads to decapping of the mesopores and release of the detectable fluorescent dye.

K. Breuker and B. Ganisl (University of Innsbruck, Austria) report on their findings towards the question whether electron capture dissociation cleaves protein disulfide bonds. They discuss their results on electron capture dissociation measurements of disulfide-bonded proteins, ecotin, trypsin inhibitor, insulin, aprotinin, and peptides K8- and R8-vasopressin, and conclude that it is nearly impossible to predict whether and to what extent disulfide bonds are preserved during collisionally activated dissociation (CAD), electron capture dissociation (ECD), or electron transfer dissociation (ETD).

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ChemistyOpen’s Issue 4 is now available via Wiley Online Library and the journal’s homepage: www.chemistryopen.org.

This issue for the first time holds a Thesis Summary in the journal’s unique Thesis Treasury section. It allows scientists to publish a short summary of their PhD thesis and make it openly accessible to all. See the first contribution online, where H. Varela nicely summarizes his PhD thesis on Spatiotemporal Pattern Formation during Electrochemical Oxidation of Hydrogen on Platinum.

Again ChemistryOpen offers topics from all areas of chemistry. Wagenknecht et al. optimize the properties of dual-emitting oligonucleotide probes by restricting its conformations using pyrrolidinyl PNA. To visualize b cells using PET imaging, Weissleder et. al modify an exendin-4 derivative with ¹⁸F via trans-cyclooctene/tetrazine cycloaddition. An efficient and simple synthetic strategy from azabicylo[4.1.0]heptenes to arylhexahydroisoquinolines is presented by Chung et al. In another Full Paper, Autschbach and co-worker perform time-dependent DFT calculations to study the long-range exciton coupling circular dichroism of tetraphenylporphorin.

And remember, all articles published in ChemistryOpen are fully open access and freely available to all. Click here  to browse the latest issue!