Abstract: The PDF Data Extractor (PDE) R package is designed to perform comprehensive literature reviews for scientists at any stage in a user-friendly way. The PDE_analyzer_i() function permits the user to filter and search thousands of scientific articles using a simple user interface, requiring no bioinformatics skills. In the additional PDE_reader_i() interface, the user can then quickly browse the sentences with detected keywords, open the full-text article, when required, and convert tables conveniently from PDF files to Excel sheets (pdf2table). Specific features of the literature analysis include the adaptability of analysis parameters and the detection of abbreviations of search words in articles. In this article, we demonstrate and exemplify how the PDE package allows the user-friendly, efficient, and automated extraction of meta-data from full-text articles, which can aid in summarizing the existing literature on any topic of interest. As such, we recommend the use of the PDE package as the first step in conducting an extensive review of the scientific literature. The PDE package is available from the Comprehensive R Archive Network at https://CRAN.R-project.org/package=PDE.