“Technological hubris is ignoring the suggestions of others—even if only by neglecting to inform them of an advance. It is most common among those suffering from the curse of knowledge: scientists.
That’s why my colleagues and I seek to ensure that all gene drive research takes place in the open light of day. People deserve a voice in decisions that might affect them, and building gene drive systems behind closed doors denies them that opportunity. Even apart from the moral hazard, keeping research plans secret—as the current scientific enterprise incentivizes us to do—is appallingly inefficient and outright dangerous. It doesn’t just slow the rate of advances, thereby jeopardizing our ability to sustain our civilization; it practically invites global catastrophic risk. No one, be they science-fiction author or Austin Burt himself, anticipated a form of gene drive as versatile as is theoretically enabled by CRISPR. What else have we not anticipated that this time might be truly dangerous? And given this possibility, why on earth do we send out small teams of ultra-specialists, mostly working on their own and in secret, to find and open every technological box they can? Better to default to open research plans, enabling diverse teams to evaluate new advances, implementing measures to obscure and counter anything deemed truly dangerous, than to proceed blindly.
Of course, any wholesale restructuring of the scientific enterprise would also be an act of reckless hubris. My personal rule of ecological engineering: start local and scale up only if warranted. In this case, the best “local test” is the field of gene drive research. Scientific journals, funders, policymakers, and intellectual property holders should change the incentives to ensure that all proposed gene drive experiments are open and responsive.
The message from fiction and reality is clear: Scientists should hold themselves morally responsible for all consequences of their work. The least we can do is muster enough humility to ask for help….”