Our new broad scope journal, Cancer Medicine has now published issue 1.1.
This issue brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe.
Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the inaugural issue.
Interleukin-1? mediates metalloproteinase-dependent renal cell carcinoma tumor cell invasion through the activation of CCAAT enhancer binding protein ?
Brenda L. Petrella and Matthew P. Vincenti
Summary: Inflammation is a poor prognostic indicator for renal cell carcinoma (RCC), and metastatic RCC remains a major medical concern, as it is refractory to standard therapies. We hypothesized that inflammatory cytokines in the tumor microenvironment directly affect RCC tumor cells to progress to a metastatic phenotype. We report that IL-1? stimulated RCC tumor cell invasion in a mechanism that required the activation of the CCAAT Enhancer Binding Protein-? (CEBP?) transcription factor and the subsequent induction of Matrix Metalloproteinases (MMPs).
ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells
Byung-Kwon Choi, Xuejun Fan, Hui Deng, Ningyan Zhang and Zhiqiang An
Summary: This study reports that an anti-HER2 antibody increased proliferation and migration of the low HER2 expressing MCF7 cancer cells by inducing HER3/EGFR dimerization independent of HER3 ligand stimulation. The results suggest that equilibrium of dimerization among the HER receptors can be perturbed by HER targeting antibodies and HER3 is a key sensor in the regulation of HER family receptor signaling.
RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer
Hidefumi Sasaki, Shigeki Shimizu, Yoichi Tani, Masahiko Maekawa, Katsuhiro Okuda, Keisuke Yokota, Masayuki Shitara, Yu Hikosaka, Satoru Moriyama, Motoki Yano and Yoshitaka Fujii
Summary: Original FISH probes were used for KIF5B/RET translocation in lung adenocarcinimas.
We hope you enjoy reading this first issue! Cancer Medicine is a peer reviewed, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences. Submit your paper here > Sign up for e-toc alerts here >