ChemistryOpen’s sixth Issue is now online and free to read, download and share.
This last issue in 2012 covers topics ranging from bibliometrics and oxidative rearrangements to molecular recognition in glycoaldehyde.
R. Martínez-Mánez and co-workers present their work on detecting finasteride, a steroid used in sports for doping. To do so, they use mesoporous silica nanoparticles that are functionalized with a finasteride derivative. They then load the nanoparticles with the fluorescent dye, rhodamine B, and cap them with an anti-finasteride antibody. The dye is trapped inside the mesopores and is only released when surrounding finasteride competes for binding to the antibodies, which then leads to decapping of the mesopores and release of the detectable fluorescent dye.
K. Breuker and B. Ganisl (University of Innsbruck, Austria) report on their findings towards the question whether electron capture dissociation cleaves protein disulfide bonds. They discuss their results on electron capture dissociation measurements of disulfide-bonded proteins, ecotin, trypsin inhibitor, insulin, aprotinin, and peptides K8- and R8-vasopressin, and conclude that it is nearly impossible to predict whether and to what extent disulfide bonds are preserved during collisionally activated dissociation (CAD), electron capture dissociation (ECD), or electron transfer dissociation (ETD).