Physiological Reports Issue 1.4 Now Published

Physiological ReportsThe latest issue of Physiological Reports has now closed. This is the fourth issue of this new open access journal and submissions continue to be strong. We have now accepted 100 articles in the journal. Authors are encouraged to continue to submit their papers across all areas of physiology to this journal using the online submission site.

Below are the ‘editor’s choice’ articles for this issue:

Unique growth pattern of human mammary epithelial cells induced by polymeric nanoparticles
Rajaa Hussien, Bertrand H. Rihn, Housam Eidi, Carole Ronzani, Olivier Joubert, Luc Ferrari, Oscar Vazquez, Daniela Kaufer and George A. Brooks

phy227-toc-0001   Summary: We describe how nanoparticles can be used to draw serum growth factors to cell surfaces.







Obese melanocortin-4 receptor-deficient rats exhibit augmented angiogenic balance and vasorelaxation during pregnancy
Frank T. Spradley, Ana C. Palei and Joey P. Granger

phy281-toc-0001 Summary: Obese normal pregnant melanocortin-4-receptor (MC4R) deficient (+/?) rats compared to lean MC4R+/+ rats have similar placental levels of angiogenic (VEGF, A) and antiangiogenic (sFlt-1, B) factors and comparable angiogenic balance (C). However, white adipose tissue from obese normal pregnant rats have greater VEGF (D), sFlt-1 (E), and angiogenic balance (F). These data indicate that white adipose tissue is an important source of angiogenic factors in normal pregnant, obese animals.


Candidate genes for limiting cholestatic intestinal injury identified by gene expression profiling
Samuel M. Alaish, Jennifer Timmons, Alexis Smith, Marguerite S. Buzza, Ebony Murphy, Aiping Zhao, Yezhou Sun, Douglas J. Turner, Terez Shea-Donahue, Toni M. Antalis, Alan Cross and Susan G. Dorsey


Summary: Following cholestasis, failure of the intestinal barrier with decreased intestinal resistance, increased bacterial translocation, and increased episodes of sepsis has been well described; however, the exact mechanisms remain poorly understood. Anecdotal clinical evidence as well as our own animal data suggests a genetic predisposition to exaggerated cholestatic injury. In this study, a microarray analysis in two strains of inbred mice demonstrated changes in intestinal gene expression not only due to cholestasis but also due to the particular murine strain, implicating novel mechanisms involving the growth hormone pathway, the acute phase response, and the innate immune response.

Evidence for centrally induced cholinergic vasodilatation in skeletal muscle during voluntary one-legged cycling and motor imagery in humans
Kei Ishii, Kanji Matsukawa, Nan Liang, Kana Endo, Mitsuhiro Idesako, Hironobu Hamada, Kazumi Ueno and Tsuyoshi Kataoka


Summary: The aim of this study was to examine using near-infrared microscopy whether sympathetic cholinergic vasodilatation mediates the increases in blood flows of both noncontracting and contracting vastus lateralis (VL) muscles during voluntary one-legged exercise. Atropine (10 µg/kg iv) blunted the increases in concentration of oxygenated-hemoglobin in the bilateral VL at the start of one-legged cycling and during mental imagery of the exercise. Thus, it is likely that central command evokes cholinergic vasodilatation equally in bilateral VL muscles during voluntary one-legged cycling and motor imagery.