Cancer Medicine Issue 2:5 is online and avilable to read now!
The journal brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe. The journal is fully open access so all of our articles are freely immediately available to read, download and share.
You can access all our content here.
Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the October issue.
Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNF?-mediated apoptosis
Bethanie L. Morrison, Michael E. Mullendore, Luke H. Stockwin, Suzanne Borgel, Melinda G. Hollingshead and Dianne L. Newton
Summary: The mechanistic basis for oxyphenisatin acetate anti-cancer activity remains unresolved. This study demonstrates that exposure is associated with an acute nutrient deprivation response leading to translation inhibition, induction of autophagy, transient estrogen receptor (ER) stress and mitochondrial dysfunction. Ultimately these effects promote apoptosis induction, which in ER+ breast cancer cells is mediated by autocrine TNF? production. This is the first study implicating a nutrient deprivation response as central to the downstream effects of oxyphenisatin acetate.
Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor
Theodora Fifis, Linh Nguyen, Cathy Malcontenti-Wilson, Lie Sam Chan, Patricia Luiza Nunes Costa, Jurstine Daruwalla, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Mark Waltham, Erik W. Thompson and Christopher Christophi
Summary: Vascular disruptive treatments effectively destroy over 90% of solid tumors with minimal effects on host tissues but a viable rim of cells persists in the tumor periphery that leads to recurrence. An immediate and widespread epithelial to mesenchymal transition (EMT) occurs within the viable rim after treatment that may be responsible for this resistance to treatment. Targeting EMT in combination with vascular disruptive agents or other therapies in the clinic may improve treatment outcomes.
Preimmunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation
Koji Suzuki, Kouichirou Aida, Reina Miyakawa, Kenta Narumi, Takeshi Udagawa, Teruhiko Yoshida, Yusei Ohshima and Kazunori Aoki
Summary: Autologous hematopoietic stem cell transplantation (HSCT) can create an environment strongly supporting the enhancement of antitumor immunity. However, it was rare to cure tumor-bearing mice. We showed that the pre-immunization of donor lymphocytes by intratumoral interferon alpha gene transfer was highly effective in enhancing the antitumor immunity of HSCT and eradicated tumors.